1、A 25-year-old G3P0 white female in her 6th week of gestation comes to the antenatal clinic. She feels fine except for mild nausea. Her obstetric history is significant for two first trimester miscarriages. She is currently taking folic acid and iron supplementation. She does not smoke, but she drinks alcohol on social occasions. She is in a monogamous relationship with her husband. She has never been diagnosed with or treated for any sexually transmitted diseases. Laboratory studies reveal the following: VDRL positive
Urinalysis does not show any blood or protein. What is the most appropriate next step in the management of this patient?
A、Benzathine penicillin
B、Benzathine penicillin and azithromycin
C、Low molecular weight heparin
D、Prednisone
Answer:(C)
The correct answer is C. While this patient's two prior miscarriages may have been a coincidence, her presentation is concerning for an underlying disorder contributing to recurrent pregnancy losses. The VDRL test is often administered to pregnant patients and has a high sensitivity for syphilis. However, the specificity of this test is somewhat low and the diagnosis should be confirmed with the FTA-ABS test Antiphospholipid antibody syndrome (APS) is a common cause of a false positive VDRL in women of this age group. APS can promote arterial and venous thromboses and a resultant tendency toward spontaneous abortions Thrombocytopenia and a prolonged PTT are also common findings in affected patients. While further testing should probably be performed to confirm the diagnosis, this patient should be started on low molecular weight heparin (LMWH) to reduce the nskto her current pregnancy.
(Choice A) Benzathine penicillin is unnecessary as this patient is unlikely to have syphilis since the FTA-ABS is negative Her false positive VDRL is likely secondary to APS.
(Choice B) This patient does not have a bacterial infection that would benefit from the addition of azithromycin
(Choice D) The role of corticosteroids in APS is controversial and currently not the standard of care.